Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease
Completed · Not applicable
Conditions studied: Healthy Aging, Alzheimer Disease
In brief
The overall goal is to characterize the acute exercise response as it relates to brain glucose metabolism in aging and Alzheimer's Disease (AD). The study team will also examine lactate metabolism, relationships with cognition, and the effect of exercise intensity.
Key facts
- Study ID
- NCT04299308
- Run by
- University of Kansas Medical Center
- People needed
- 60
- Starts
- 2020-08-28
- Expected to finish
- 2023-10-31
- Last updated by the study team
- 2025-07-23
Who can join
Age: 60 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 60 and older
- Stable medication doses (>1month)
- Post-menopausal
- Diagnosis of either Nondemented (CDR 0) or Probable AD (CDR 0.5 or 1 only)
You may not qualify if…
- Inability to provide consent
- Diagnosis of insulin-dependent (Type 1) Diabetes Mellitus
- Recent ischemic heart disease (<2 years)
- Diagnosis of an clinically significant chronic disease including cardiovascular disease (CVD), other metabolic diseases (e.g., thyroid), cancer, human immunodeficiency virus (HIV), or acquired immunodeficiency syndrome
- Excluded from or unable to complete an MRI scan
- Any Neurological disorders that have the potential to impair cognition or brain metabolism (e.g., Parkinson's disease, stroke defined as a clinical episode with neuroimaging evidence in an appropriate area to explain the symptoms).
- Clinically significant depressive symptoms that may impair cognition, abnormalities in B12, rapid plasma regain (RPR), or thyroid function that may impair cognition, use of psychoactive and investigational medications, and significant visual or auditory impairment
Where it is running
- Univeristy of Kansas Medical Center — Kansas City, Kansas, United States
Full record on ClinicalTrials.gov
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