Introduction of ACI for Cartilage Repair

Recruiting now · Not applicable

Conditions studied: Articular Cartilage Defect, Chondral Defect, Osteochondritis

In brief

This study was aimed to evaluate effectiveness and safety of autologous chondrocyte suspension for treatment of knee articular cartilage defects.

Key facts

Study ID

NCT04296487

Run by

Centre Hospitalier Universitaire Vaudois

People needed

218

Starts

2017-09-01

Expected to finish

2030-09-01

Last updated by the study team

2026-03-11

Who can join

Age: 15 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 15 and 50.
• Lesions classified as ICRS Grade III or IV and smaller than 15 cm2
• Lesions that have failed prior therapy (conservative or surgical treatment ≥ six months)
• Subjects who understand and sign the consent form for this study

You may not qualify if…

• Body mass index (BMI) of 35 or more
• Osteoarthritis or rheumatoid arthritis
• Diffuse lesion
• Uncorrected mal-alignment, ligamentous instability, or meniscal tear
• Presence of growth cartilage (15-18 years old)
• Active smoking or drug consumption
• Women who are pregnant
• Positive serology for HIV-1 or HIV-2, Hepatitis B and C and syphilis
• Proven allergy to porcine collagen, penicillin and gentamicin
• Poor compliance

Where it is running

• Centre Hospitalier Universitaire Vaudois - CHUV — Lausanne, Canton of Vaud, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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