Neurobehavioral Mechanisms of Cocaine Choice

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Cocaine Use Disorder

In brief

The objective of this protocol is to use a drug-vs-money choice task, reinforcement learning modeling and fMRI to determine the neurobehavioral and neurobiological decision-making "profile" associated with the decision to take cocaine and the reduced cocaine choice that occurs during a behavioral intervention (alternative money reinforcer) that models contingency management.

Key facts

Study ID

NCT04296006

Run by

Joshua A. Lile, Ph.D.

People needed

15

Starts

2021-01-15

Expected to finish

2025-02-01

Last updated by the study team

2025-04-03

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Recent cocaine use, otherwise healthy

You may not qualify if…

• Laboratory results outside of clinically acceptable ranges, history of or current serious physical or psychiatric disease

Where it is running

• Laboratory of Human Behavioral Pharmacology — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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