Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function

Completed · Not applicable

Conditions studied: Neonatal, Premature Birth, Respiratory Distress Syndrome

In brief

This is a study to see if an extra 2 weeks of continuous positive airway pressure (CPAP) in stable preterm infants in the neonatal intensive care unit (NICU) can cause increased lung growth and lung function in the infants as measured at 6 months of age by pulmonary function testing.

Key facts

Study ID

NCT04295564

Run by

Cynthia McEvoy

People needed

100

Starts

2020-01-10

Expected to finish

2024-03-15

Last updated by the study team

2025-08-17

Who can join

Age: 0 and older, up to 0. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Infants born at >24 to ≤ 32 weeks gestation
• Treated with CPAP for ≥ 24 hours for respiratory distress (either as initial therapy or following extubation)

You may not qualify if…

• Significant congenital heart disease
• Major malformations
• Chromosomal anomalies
• Culture proven sepsis at consent
• Complex maternal medical conditions
• Clinical instability
• Multiple gestations > twins
• <3rd or >97th percentile for weight85
• Participating in another neonatal randomized clinical trial with a competing outcome
• Mother/legal guardian without stable method of communication

Where it is running

• Doernbecher Neonatal Care Center at Oregon Health & Science University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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