Optimal Dosing For Low-Dose Aspirin Chemoprophylaxis For VTE Following Total Joint Arthroplasty

Recruiting now · Phase 2

Conditions studied: Venous Thromboembolism

In brief

This research study is attempting to answer the question of whether 81 mg aspirin once daily is as effective as 81 mg aspirin twice daily in preventing blood clots after total joint replacement surgery.

Key facts

Study ID

NCT04295486

Run by

University of Miami

People needed

5478

Starts

2021-03-01

Expected to finish

2027-03-01

Last updated by the study team

2026-03-11

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• > 18 years of age
• Planning to undergo a primary total hip or knee arthroplasty

You may not qualify if…

• High risk patients for VTE as defined by:
• History of venous thromboembolism
• Active malignancy
• Known pro thrombotic condition
• BMI > 40
• Patients requiring anticoagulation for pre-existing conditions
• Patients with the contraindication for use of aspirin or nonsteroidal antiinflammatory drugs for reasons such as peptic ulcer disease, intolerance, others.
• Patients not fluent in the language of the informed consent form
• Prisoners
• Pregnancy
• Reported to have mental illness or belonging to a vulnerable population

Where it is running

• University of Miami Hospital — Miami, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

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