Age-Related Effects of THC

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Tolerance, Adolescent Behavior, THC

In brief

Increased accessibility to cannabis and its primary psychoactive constituent THC has raised public health concerns. One major concern surrounds the potential risks associated with acute THC intoxication and who might be most at risk. A second major concern is the need to develop sensitive measures that can detect THC intoxication after recent use and enable robust comparisons of intoxication to determine sources of risk. One potential source of risk is age, specifically during the period of adolescence.

Key facts

Study ID

NCT04294966

Run by

University of Chicago

People needed

24

Starts

2020-03-10

Expected to finish

2021-05-01

Last updated by the study team

2023-11-09

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-20 years old OR 30-40 years old
• Body Mass Index 19-26
• High school education, fluent in English
• Occasional cannabis users ( 0 times in past 30 days AND used cannabis no more than 20 times in lifetime)

You may not qualify if…

• History of daily cannabis use
• Past or present severe substance use disorder
• Current or past diagnosis with drug treatment for psychosis/bipolar/schizophrenia
• Cardiovascular illness, high blood pressure, abnormal electrocardiogram
• Current medications
• Pregnant or planning to become pregnant

Where it is running

• University of Chicago Hospital — Chicago, Illinois, United States
• University of Chicago — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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