Fuel Utilization, Diet Composition, and Exercise in African American Women
Completed · Not applicable
Conditions studied: Obesity, Diabetes, Insulin Resistance
In brief
African American women have a high prevalence of obesity and type 2 diabetes and do not optimally burn fat and carbohydrates in response to changes in these nutrients in their diets. This research project seek to determine if high intensity interval training (HIIT) exercise training can help healthy, but inactive, premenopausal, non-diabetic women increase their bodies' use of fat and carbohydrates when provided with a high fat or low fat diets. In this study, investigators will measure the rate at which fat is burned in response to weight maintaining low-fat and high-fat diets and how exercise may affect these responses.
Key facts
- Study ID
- NCT04293367
- Run by
- Icahn School of Medicine at Mount Sinai
- People needed
- 28
- Starts
- 2009-06-01
- Expected to finish
- 2013-11-20
- Last updated by the study team
- 2020-03-03
Who can join
Age: 20 and older, up to 40. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- African American descent and all four grandparents reported as African Americans
- DNA will also be collected so admixture could be measured post study
- Reported good health (blood work, Hx and PE)
- Non-diabetic (OGTT)
- Pre-menopausal, Age range 20-40 years BMI range of 25-40, with regular menstrual periods
- Sedentary (exercise no more than 2 times/week, for one hour or spend no more than 1000 - 1500 Kcal/wk in physical activity as determined by a Paffenbarger questionnaire).
You may not qualify if…
- Any cardiac or pulmonary illnesses which may interfere with their capacity to exercise
- Active smoker
- Consume more than 2 oz. of ethanol/day
- Weight change greater than + 2 kg in the past 3 months
- Currently taking medications or have any physical conditions which may affect insulin action and/or lipid metabolism or have hyperlipidemia (plasma triglyceride greater than or equal to 350 mg/dl or total cholesterol levels greater than or equal to 300 mg/dl).
- Metal implants (ex: pacemaker, implanted jewelry, etc)
- 1st degree family history of type diabetes 2 diabetes (Will be noted but will not constitute an exclusionary criteria).
- The subjects' usual diets will be evaluated by the Block 98.2 Food Frequency Questionnaire (BDDS, Berkeley, CA).
Where it is running
- Mount Sinai St. Luke's Clinical Research Unit — New York, New York, United States
Full record on ClinicalTrials.gov
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