Individualized Brain Stimulation to Improve Mobility in Alzheimer's Disease

Running, not enrolling · Not applicable · Has a placebo group

Conditions studied: Alzheimer Dementia, Presenile Alzheimer Dementia, Aging

In brief

The objective of this study is to conduct a pilot, randomized sham-controlled trials to determine the feasibility and effects of a 10-session personalized tDCS intervention targeting the left dorsolateral prefrontal cortex on cognitive function, dual task standing and walking, and other metrics of mobility in 24 older adults with mild AD living in supportive housing.

Key facts

Study ID

NCT04289402

Run by

Hebrew SeniorLife

People needed

11

Starts

2020-01-31

Expected to finish

2027-12-31

Last updated by the study team

2026-04-27

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and women aged 65 and older living within supportive housing facilities
• Mild Alzheimer's disease (AD) defined by the combination of 1) at least mild cognitive impairment defined as a modified TICS score of ≤ 34, 2) informant-report of Instrumental Activities of Daily Living impairment as defined as a score of ≥ 6 on the NACC Functional Activities Questionnaire, and 3) a Clinical Dementia Rating score of 1.

You may not qualify if…

• Inability to secure informant participation
• Unwillingness to cooperate or participate in the study protocol
• An inability to ambulate without the assistance of another person (canes or walkers allowed)
• A clinical history of stroke, Parkinson's disease or parkinsonian symptoms, multiple sclerosis, normal pressure hydrocephalus, or other neurological conditions outside of mild AD.
• Any report of severe lower-extremity arthritis or physician-diagnosis of peripheral neuropathy
• Use of antipsychotics, anti-seizure, benzodiazepines, or other neuroactive medications
• Severe depression defined by a Center for Epidemiologic Studies Depression scale score greater than 16
• Any report of physician-diagnosis of schizophrenia, bipolar disorder, or other psychiatric illness
• Contraindications to MRI or tDCS, including reported seizure within the past two years, use of neuropsychological-active drugs, the risk of metal objects anywhere in the body, self-reported presence of specific implanted medical devices (e.g., deep brain stimulator, medication infusion pump, cochlear implant, pacemakers, etc.), or the presence of any active dermatological condition, such as eczema, on the scalp

Where it is running

• Hebrew Rehabilitation Center — Roslindale, Massachusetts, United States

Full record on ClinicalTrials.gov

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