Safety and Efficacy Study of VIS649 for IgA Nephropathy

Completed · Phase 2 · Has a placebo group

Conditions studied: Immunoglobulin A Nephropathy, Glomerular Disease, IgAN

In brief

The purpose of this study is to evaluate the efficacy and safety of VIS649 in participants with immunoglobulin A (IgA) Nephropathy (IgAN)

Key facts

Study ID

NCT04287985

Run by

Otsuka Pharmaceutical Development & Commercialization, Inc.

People needed

155

Starts

2020-07-20

Expected to finish

2023-06-18

Last updated by the study team

2026-04-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants are eligible to be included in the study only if all of the following criteria apply:
• Participant is a male or female ≥ 18 years of age at the time of signing the informed consent.
• Participant must have biopsy-confirmed IgAN.
• Participant has medical records showing they have been on stable and maximally tolerated doses of either ACEI or ARB, as per local SOC and applicable guidelines, for at least 3 months preceding screening. Participants should optimally be on at least 50% of the maximum recommended dose of these agents; however, if a participant is on their maximally tolerated dose (and this is < 50% of the maximum recommended dose) and has been on this dose for at least 3 months, they may be enrolled. Participants who are unable to tolerate ACEI/ARB therapy may be eligible for participation in the study if their overall management of IgAN, including BP control, is as per local SOC and applicable guidelines.
• Participants must have screening uPCR ≥ 0.75 g/g measured from a 24-hour urine or 24-hour urine protein ≥ 1.0 g/d, as measured from 24-hour urine collection. The proteinuria should be assessed when the participant is considered to be in a steady state with no recent heavy exercise, fever, or other potential issues that could impact the result.
• Participants must have eGFR ≥ 45 mL/min/1.73 m² using the CKD-EPI formula.
• Participant's serum Ig values must meet specified criteria
• Female participants of childbearing potential must have a negative serum pregnancy test prior to the first dose.
• Participant is willing to adhere to contraceptive requirements.
• Participant or a legally authorized representative is able and is willing to give voluntary written informed consent

You may not qualify if…

• Participants are excluded from the study if they meet any of the following criteria:
• Participant has secondary forms of IgAN as defined by the treating physician.
• Participant has co-existing CKD, other than IgAN.
• Participant has evidence of additional pathological findings in the kidney biopsy (eg, diabetic kidney disease, membranous nephropathy, or lupus nephritis). However, hypertensive vascular changes are acceptable.
• Participant has kidney biopsy MEST or MEST-C score as defined in the protocol.
• Participant has nephrotic syndrome.
• Participant has received a solid organ transplant, including kidney.
• Participant has received bone marrow or hematologic stem cell transplantation.
• Participant is currently receiving systemic immunosuppression (excluding topical, ophthalmic, per rectum, or inhaled corticosteroids).
• Participant has received treatment with systemic corticosteroid therapy within 16 weeks of initial screening.
• Participant has received treatment with a systemic immunosuppressive agents within 16 weeks of initial screening.
• Participant has any chronic infectious disease.
• Participant has acute infectious disease at the time of screening.
• Participant has Type 1 diabetes.
• Participant has uncontrolled Type 2 diabetes, as evidenced by a screening hemoglobin A1c value > 8%.
• Participant has uncontrolled BP (> 140 mm Hg systolic or > 90 mm Hg diastolic)
• Participant has a history of chronic autoimmune neurodegenerative disorder such as multiple sclerosis.
• Participant has a known allergy or intolerance to any component of the study intervention.
• Participant is breastfeeding.
• Participant has poorly compensated or controlled ischemic heart disease or cardiomyopathy, as judged by the Investigator.
• Participant has chronic obstructive pulmonary disease (COPD) or asthma that has required systemic steroid therapy during the prior year.
• Participant has known cirrhosis or liver dysfunction, defined as presence of coagulopathy, platelet count < 100,000/μL or alanine aminotransferase > 3× upper limit of normal.
• Participant has active malignancy or is receiving chemotherapy for malignancy, except for nonmelanoma skin cancers and cervical carcinoma in situ. Participants with prior malignancy who have been documented to be cancer-free for ≥ 5 years may be enrolled.
• Participant is planning or scheduled to undergo a tonsillectomy. Prior tonsillectomy is acceptable (if greater than 6 months prior to screening).
• Participant enrolled in another investigational drug or device study within 3 months prior to initial screening.

Where it is running

• Visterra Investigational Site — Los Angeles, California, United States
• Visterra Investigational Site — Oxnard, California, United States
• Visterra Investigational Site — Palo Alto, California, United States
• Visterra Investigational Site — Stanford, California, United States
• Visterra Investigational Site — Denver, Colorado, United States
• Visterra Investigational Site — Lawrenceville, Georgia, United States
• Visterra Investigational Site — Baton Rouge, Louisiana, United States
• Visterra Investigational Site — New Orleans, Louisiana, United States
• Visterra Investigational Site — Baltimore, Maryland, United States
• Visterra Investigational Site — Tupelo, Mississippi, United States
• Visterra Investigational Site — New York, New York, United States
• Visterra Investigational Site — Chapel Hill, North Carolina, United States
• Visterra Investigational Site — Columbus, Ohio, United States
• Visterra Investigational Site — Bethlehem, Pennsylvania, United States
• Visterra Investigational Site — Houston, Texas, United States
• Visterra Investigational Site — Houston, Texas, United States
• Visterra Investigational Site — New Lambton Heights, New South Wales, Australia
• Visterra Investigational Site — Saint Leonards, New South Wales, Australia
• Visterra Investigational Site — Nambour, Queensland, Australia
• Visterra Investigational Site — Nedlands, Western Australia, Australia
• Visterra Investigational Site — Calgary, Alberta, Canada
• Visterra Investigational Site — Brampton, Ontario, Canada
• Visterra Investigational Site — Montreal, Quebec, Canada
• Visterra Investigational Site — Hong Kong, HK, Hong Kong
• Visterra Investigational Site — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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