Potassium Flux in Hemodialysis Patients
Completed
Conditions studied: Hemodialysis
In brief
Current practice of outpatient hemodialysis entails prescription of standard electrolyte concentrations based upon patient prescription history and monthly serum electrolyte measurements. Dialysate concentration of potassium can be adjusted based on standard available concentrations including 2mmol/L and 3mmol/L. Standard available dialysate concentration of Magnesium is 0.5mmol/L (which is not ordinarily adjusted further). Potassium and Magnesium are not routinely measured before or after each dialysis, therefore serum levels are largely unknown outside of once monthly measurements. This study aims to further study this correlation of electrolyte fluctuations (potassium and magnesium) and cardiac arrhythmias/heart rate variability in the ESRD population.
Key facts
- Study ID
- NCT04287010
- Run by
- Washington University School of Medicine
- People needed
- 25
- Starts
- 2019-05-21
- Expected to finish
- 2020-11-30
- Last updated by the study team
- 2021-01-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age >18 years
- Consistent thrice weekly in center hemodialysis as defined as no missed sessions in the last 30 days.
- Goal Kt/V Urea (>1.2, which suggests adequate dialysis based on KDOQI guidelines) for at least 3 months
- Serum potassium 3.5-8.0 mEq/L
- Hemoglobin of >8.0g/dL
You may not qualify if…
- Age <18 years
- Evidence of residual renal function as defined by >100mL of urine output per day
- Those whom do not have capacity to consent
- Change in dialysis prescription within the past 30 days
- 12-lead ECG shows non-sinus cardiac rhythm (atrial fibrillation, atrial flutter, or paced rhythm)
Where it is running
- Washington Univeristy in St Louis — St Louis, Missouri, United States
Full record on ClinicalTrials.gov
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