Memory Retrieval and Encoding Investigated by Neural Stimulation

Running, not enrolling · Not applicable

Conditions studied: Epilepsy Intractable

In brief

The purpose of this research is to understand biomarkers of human memory through correlational analyses and to use focal electrical stimulation as a causal manipulation to understand how biomarkers of memory relate to other brain states and behavioral measures.

Key facts

Study ID

NCT04286776

Run by

University of Pennsylvania

People needed

800

Starts

2014-10-12

Expected to finish

2024-12-31

Last updated by the study team

2024-11-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Expected to undergo intracranial implantation and postoperative electroencephalographic monitoring as part of a standard clinical procedure for the treatment of pharmacologically resistant epilepsy
• Age 18 or older

You may not qualify if…

• Any physical or cognitive disability or illness that would limit their ability to perform cognitive tasks
• Any medical condition that would, in the investigator's opinion, limit the subject's participation in the study.
• Unable or unwilling to provide informed consent
• MRI contraindications
• Standard clinical care includes a pregnancy test for female patients prior to the surgical implantation of the electrodes. Pregnant women are not surgically implanted.

Where it is running

• University of Colorado, Denver — Aurora, Colorado, United States
• Emory University Hospital — Atlanta, Georgia, United States
• National Institute of Neurological Disorders and Stroke — Bethesda, Maryland, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire, United States
• Columbia University — New York, New York, United States
• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Thomas Jefferson University Hospital — Philadelphia, Pennsylvania, United States
• UT Southwestern Medical Center — Dallas, Texas, United States
• University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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