Brain Connections for Arm Movement After Stroke
Recruiting now · Not applicable
Conditions studied: Stroke, Brain Disease, Central Nervous System Diseases, Nervous System Diseases, Cardiovascular Diseases
In brief
The purpose of this study is to use Transcranial Magnetic Stimulation (TMS) while subjects are making reaching movements in a robotic arm device in order to discover how different brain areas control movement before and after stroke and when these brain areas are most sensitive to TMS.
Key facts
- Study ID
- NCT04286516
- Run by
- VA Office of Research and Development
- People needed
- 76
- Starts
- 2020-01-10
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-06-02
Who can join
Age: 45 and older, up to 90. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Inclusion Criteria (control participants):
- Be 45-90 years of age
- Have adequate language and neurocognitive function to participate in training and testing
- Be medically stable to participate in the study
- Be English speaking
- Inclusion Criteria (participants with stroke):
- Be 45-90 years of age
- Clinically defined, unilateral, hemiparetic stroke with radiologic exclusion of other possible diagnosis
- Stroke onset at least 6 months before enrollment
- Subcortical stroke (ex: internal capsule, deep white matter of posterior frontal lobe)
- Present with mild to moderate arm dysfunction
- Be medically stable to participate in the study
- Be English speaking
You may not qualify if…
- (for both groups)
- Unable to give informed consent
- Have a serious complicating medical illness that would preclude participation
- Contractures or orthopedic problems limiting range of joint motion in the potential study arm or other impairments that would interfere with the study activities
- Visual loss such that the subject would not be able to see the test patterns on the robot computer monitor
- Unable to comply with requirements of the study
- Enrollment in another greater-than-minimal risk study
- Presence of medical condition or implant that prevents safe administration of TMS or MRI
- Pregnancy
Where it is running
- VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA — Pittsburgh, Pennsylvania, United States (enrolling)
Full record on ClinicalTrials.gov
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