Achieving Nutritional Adequacy Of Vitamin K With An Egg/Plant-Based Food Pairing
Completed · Not applicable
Conditions studied: Nutritional Requirements
In brief
Malnutrition of the fat-soluble nutrient vitamin K (phylloquinone; PQ) is problematic. Since PQ is rich in plant foods (e.g. spinach) that are mostly absent of accessible lipid, dietary patterns that can potentiate PQ bioavailability by pairing vegetables with lipid-rich foods have been emphasized. The purpose of this study is to use deuterium-labeled spinach (containing stable isotopes of PQ) to validate eggs as a dietary tool to improve PQ bioavailability directly from a model plant food, and hence achieve nutrient adequacy. It is expected that compared with deuterium-labeled spinach alone, co-ingestion of eggs will increase plasma bioavailability of spinach-derived deuterium-labeled PQ without affecting time to maximal concentrations or half-lives. Further, phospholipid-rich egg yolk lipid will enhance nutrient bioavailability compared with vegetable oil. The outcomes will serve as the foundation for easy-to-implement message of public health importance in support of whole eggs and egg whites as part of a plant-based dietary pattern.
Key facts
- Study ID
- NCT04286321
- Run by
- Ohio State University
- People needed
- 10
- Starts
- 2021-06-01
- Expected to finish
- 2024-07-15
- Last updated by the study team
- 2025-06-03
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Body Mass Index (BMI) = 19-25 kg/m2
- Normolipidemic (total cholesterol <240 mg/dL; triglyceride <150 mg/dL)
- Fasting glucose <100 mg/dL
- Normal hematocrit level (41%-50% for men and 36%-48% for women)
- Normal hemoglobin level (13.5-17.5 g/dL for men and 12.0-15.5 g/dL for women)
- No use of dietary supplements for >1 month
- No use of medications that affect lipid or glucose metabolism
- Non-smoker
- No history of gastrointestinal disorders
You may not qualify if…
- Egg allergy
- Alcohol intake > 2 drinks per day
- Aerobic activity >7 h/wk
- Body mass change >2 kg in the past 1 month
- Women who are pregnant, lactating, or initiated or changed birth control in the past 3 month
- Vegetarian
Where it is running
- Bruno Lab — Columbus, Ohio, United States
Full record on ClinicalTrials.gov
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