Prospective Natural History Study of Retinitis Pigmentosa

Running, not enrolling · Not applicable

Conditions studied: Retinitis Pigmentosa

In brief

This is natural history study of rods and cones degenerations in patients with Retinitis Pigmentosa (RP) caused by pathogenic mutations in RHO, PDE6a or PDE6b gene mutations.

Key facts

Study ID

NCT04285398

Run by

SparingVision

People needed

82

Starts

2020-02-12

Expected to finish

2026-06-30

Last updated by the study team

2025-05-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• RP with mutations affecting the RHO, PDE6A and PDE6B genes
• Visual acuity ≥ 20/200 for at least one eye at inclusion visit
• Binocular Visual field diameter ≥ 5° as measured on the Goldmann III-4e isopter at inclusion visit
• Patients having signed the informed consent form
• Sufficient knowledge of the local language to ensure understanding of the tasks to be performed and the instructions received
• Patient affiliated to a Health Security System if they are included in a clinical site based in France (per law)

You may not qualify if…

• Patients with any other gene mutation known to be involved in RP
• Patients with other ocular disorder likely to impact the retinal function
• Pregnant or breastfeeding women

Where it is running

• UPMC Eye Center — Pittsburgh, Pennsylvania, United States
• CHNO XV-XX Paris - CIC 1423 — Paris, France

Full record on ClinicalTrials.gov

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