SPRINT: Signature for Pain Recovery IN Teens

Running, not enrolling

Conditions studied: Pain, Chronic, Pain, Joint Pain, Musculoskeletal Pain

In brief

To identify biological and phenotypic prognostic markers of recovery vs. persistence of pain and functional disability in adolescents with chronic musculoskeletal pain.

Key facts

Study ID

NCT04285112

Run by

Stanford University

People needed

275

Starts

2020-09-28

Expected to finish

2025-12-01

Last updated by the study team

2025-09-11

Who can join

Age: 11 and older, up to 18. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• The child has a diagnosis of Chronic widespread pain or Chronic primary musculoskeletal pain (other than orofacial) derived from ICD-11 (MG30.0; chronic primary pain is pain in 1 or more anatomic regions that persists for > 3 months, is associated with significant distress or functional disability and cannot be better explained by another chronic pain condition (e.g., arthritis, lupus)
• Age between 11-18 years
• Moderate to Severe Functional Disability (FDI ≥13)
• English proficiency (reading, speaking)
• Moderate to severe average pain (VAS ≥30/100)

You may not qualify if…

• Significant cognitive impairment (e.g., severe brain injury)
• Claustrophobia
• Significant medical disease (e.g., systemic or central nervous system)
• Severe psychiatric or neurological conditions (e.g., eating disorder, psychosis)
• Pregnancy
• MRI incompatibility (braces, pacemaker)
• Weight > 285 lbs.
• History of > 1 month opioid treatment.

Where it is running

• Stanford University — Palo Alto, California, United States
• Cincinnati Children's Hospital — Cincinnati, Ohio, United States
• Hospital for Sick Children — Toronto, Ontario, Canada
• University of Barcelona — Barcelona, Spain

Full record on ClinicalTrials.gov

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