Effects of a Specific Substance in Smokers

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Smoking

In brief

Although rates of cigarette use are declining, the proportion of nondaily smokers is rising, particularly among young adults. Among young adults, nondaily smoking is associated with negative health consequences and, for some, may lead to the establishment of life-long smoking patterns. The goal of this project is to understand the behavioral, psychological and neurobiological factors that contribute to cigarette use in nondaily smokers to aid the development of tailored evidence-based interventions.

Key facts

Study ID: NCT04281979
Run by: Oregon Health and Science University
People needed: 60
Starts: 2020-02-25
Expected to finish: 2025-12-31
Last updated by the study team: 2025-07-28

Who can join

Age: 21 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Participants must be 21-40 years old
Right-handed
Fluent in English
Report smoking cigarettes or e-cigarettes 1-27 days in the past month
Report binge drinking based on NIAAA criteria (5 or more drinks per occasion for males, 4 or more drinks per occasion for females) at least 1 time in the past 90 days without adverse incident

You may not qualify if…

Seeking treatment for substance use (e.g. nicotine or alcohol use)
Moderate or Severe Nicotine Dependence
Current alcohol use disorder
Illicit substance use other than marijuana use in the past year
Marijuana use more than 10 times in the past year
Major neurological or medical illness - Significant head trauma - Current use of medication affecting the central nervous system
MRI contraindications (e.g. irremovable metal on the body or pregnancy)

Where it is running

Oregon Health and Science University — Portland, Oregon, United States (enrolling)

Full record on ClinicalTrials.gov

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