DEXTENZA Compared to Topical Prednisolone in Patients Undergoing Bilateral LASIK Surgery

Status unconfirmed · Phase 4

Conditions studied: Refractive Surgery

In brief

To determine patient preference and treatment outcomes with an intracanalicular dexamethasone (0.4mg) insert compared to standard steroid drop regimen in the contralateral eye following bilateral LASIK surgery.

Key facts

Study ID

NCT04281862

Run by

Vance Thompson Vision

People needed

20

Starts

2020-01-23

Expected to finish

2020-05-01

Last updated by the study team

2020-02-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Any adult patient who is planned to undergo bilateral LASIK surgery.
• Refractive error between the 2 eyes of 2 Diopters or less
• Willing and able to comply with clinic visits and study related procedures
• Willing and able to sign the informed consent form

You may not qualify if…

• Patients under the age of 18.
• Patients who choose to have monovision after LASIK
• Patients with corneal pathology that may interfere with LASIK outcomes
• Patients who are pregnant (must be ruled out in women of child-bearing age with pregnancy test).
• Active infectious ocular or systemic disease.
• Patients with active infectious ocular or extraocular disease.
• Patients actively treated with local or systemic immunosuppression including systemic corticosteroids.
• Patients with known hypersensitivity to Dexamethasone.
• Patients with severe disease that warrants critical attention, deemed unsafe for the study by the investigator.
• Patients with a history of ocular inflammation or macular edema.
• Patients with allergy or inability to receive topical antibiotic.
• Patients on systemic non-steroidal anti-inflammatory drugs (NSAID) greater than 1,200 mg/day
• Patients with a corticosteroid implant (i.e. Ozurdex).
• Active or history of chronic or recurrent inflammatory eye disease in either eye
• Ocular pain in either eye
• Proliferative diabetic retinopathy in either eye
• Significant macular pathology detected on macular optical coherence tomography evaluation at the screening visit in either eye
• Laser or incisional ocular surgery during the study period and 6 months prior in either eye
• History of cauterization of the punctum

Where it is running

• Vance Thompson Vision ND — West Fargo, North Dakota, United States (enrolling)

Full record on ClinicalTrials.gov

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