Observing People With Desmoid-Type Fibromatosis

Recruiting now

Conditions studied: Desmoid Fibromatosis

In brief

The purpose of this study is to closely observe people with desmoid-type fibromatosis over 1 months.

Key facts

Study ID

NCT04281381

Run by

Memorial Sloan Kettering Cancer Center

People needed

100

Starts

2020-02-19

Expected to finish

2027-02-19

Last updated by the study team

2026-05-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical diagnosis of desmoid fibromatosis, either new or newly recurrent. Both patients with sporadic and FAP-associated disease will be eligible for inclusion. Patients with clinical diagnosis of desmoid (as assessed by MSK physician) but without pathologic diagnosis may be enrolled on the study to facilitate acquisition of appropriately protocoled baseline scans and allow for biospecimen collection; these patients will be replaced for purposes of analysis if pathology does not confirm clinical diagnosis.
• At least 18 years of age.
• Able to undergo cross-sectional imaging by either MRI or CT with intravenous contrast
• Disease detectable on cross-sectional imaging with target lesion measuring >/= 1 cm
• Eligible for management by active observation as assessed by primary MSK care provider
• Willing and able to sign an informed consent document

You may not qualify if…

• Symptomatic desmoid fibromatosis requiring narcotic pain control, resulting in intestinal fistulization, or requiring inpatient admission during the 3 months prior to enrollment
• Patients with intraabdominal desmoids greater than 7cm in diameter or localized within 1cm of the central mesenteric vessels and those with tumors in the head and neck
• KPS performance status </= 70 if performance status is limited due to tumor. Patients with low KPS performance status related to co-morbidities but without symptoms related to the tumor will be eligible for enrollment.
• Age less than 18 years old
• Strict contraindication for both cross-sectional MRI and CT imaging with intravenous contrast (e.g., as per standard institutional protocols regarding renal insufficiency or MRI incompatible implanted devices; patients requiring pre-medication to prevent contrast reactions will be eligible for study)
• Unable to grant reliable informed consent
• Ongoing systemic treatment for desmoid fibromatosis

Where it is running

• Memorial Sloan Kettering Cancer Center — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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