A First-in-human Study Using BDC-1001 as a Single Agent and in Combination With Nivolumab in Advanced HER2-Expressing Solid Tumors
Stopped early · Phase 1/Phase 2
Conditions studied: HER2-positive Solid Tumors, HER2-positive Breast Cancer, HER2-positive Colorectal Cancer, HER2-positive Gastroesophageal Cancer, HER2-positive Endometrial Cancer
In brief
A first-in-human study using BDC-1001 as a single agent and in combination with nivolumab in HER2 expressing advanced malignancies
Key facts
- Study ID
- NCT04278144
- Run by
- Bolt Biotherapeutics, Inc.
- People needed
- 175
- Starts
- 2020-02-24
- Expected to finish
- 2025-02-14
- Last updated by the study team
- 2025-09-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Stanford University — Palo Alto, California, United States
- Georgetown University Medical Center — Washington D.C., District of Columbia, United States
- The University of Chicago Medical Center — Chicago, Illinois, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- START Midwest — Grand Rapids, Michigan, United States
- Memorial Sloan-Kettering Cancer Center — New York, New York, United States
- Levine Cancer Institute — Charlotte, North Carolina, United States
- Stephenson Cancer Center — Oklahoma City, Oklahoma, United States
- The University of Texas MD Anderson Cancer Center — Houston, Texas, United States
- South Texas Accelerated Research Therapeutics — San Antonio, Texas, United States
- Virginia Cancer Specialists — Fairfax, Virginia, United States
- Institut Bergonie — Bordeaux, France
- Institut Paoli Calmettes — Marseille, France
- Institut Gustave Roussy — Villejuif, France
- Samsung Medical Center — Seoul, Gangnam-gu, South Korea
- Seoul National University Bundang Hospital — Seongnam-si, Gyeonggi-do, South Korea
- Asan Medical Center — Seoul, Songpa-gu, South Korea
- Hospital del Mar — Barcelona, Catalonia, Spain
- Hospital Universitario Vall d'Hebron — Barcelona, Catalonia, Spain
- Hospital Universitario Ramón y Cajal — Madrid, Madrid, Spain
- Hospital Universitario 12 de Octubre — Madrid, Madrid, Spain
Full record on ClinicalTrials.gov
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