Study of Bcl-2 Inhibitor Sonrotoclax (BGB-11417) in Participants With Mature B-Cell Malignancies
Running, not enrolling · Phase 1
Conditions studied: Mature B-Cell Malignancies
In brief
The purpose of this study is to determine the safety, tolerability; and to define the maximum tolerated dose (MTD) and Recommended Phase 2 Dose (RP2D); and to evaluate the safety and tolerability of the ramp-up dosing schedule and at the RP2D of BGB-11417 monotherapy, and when given in combination with zanubrutinib and obinutuzumab.
Key facts
- Study ID
- NCT04277637
- Run by
- BeOne Medicines
- People needed
- 437
- Starts
- 2020-03-24
- Expected to finish
- 2027-05-31
- Last updated by the study team
- 2026-06-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- UCLA Hematologyoncology — Los Angeles, California, United States
- Northwestern University — Chicago, Illinois, United States
- University of Kansas Medical Center Research Institute — Kansas City, Kansas, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Mayo Clinic Rochester — Rochester, Minnesota, United States
- University of Nebraska Medical Center — Omaha, Nebraska, United States
- John Theurer Cancer Center Hackensack University Medical Center — Hackensack, New Jersey, United States
- Columbia University Medical Center — New York, New York, United States
- Memorial Sloan Kettering Cancer Center Mskcc — New York, New York, United States
- The James Cancer Hospital and Solove Research Institute At Ohio State University — Columbus, Ohio, United States
- Upmc Hillman Cancer Center(Univ of Pittsburgh) — Pittsburgh, Pennsylvania, United States
- Md Anderson Cancer Center — Houston, Texas, United States
- Fred Hutchinson Cancer Research Center — Seattle, Washington, United States
- Concord Repatriation General Hospital — Concord, New South Wales, Australia
- Orange Health Service (Central West Cancer Care Centre) — Orange, New South Wales, Australia
- Pindara Private Hospital — Benowa, Queensland, Australia
- John Flynn Private Hospital — Tugun, Queensland, Australia
- Royal Adelaide Hospital — Adelaide, South Australia, Australia
- Flinders Medical Centre — Bedford PK, South Australia, Australia
- Box Hill Hospital — Box Hill, Victoria, Australia
- Monash Health — Clayton, Victoria, Australia
- St Vincents Hospital Melbourne — Fitzroy, Victoria, Australia
- Peter Maccallum Cancer Centre — Melbourne, Victoria, Australia
- The Alfred Hospital — Melbourne, Victoria, Australia
- Linear Clinical Research — Nedlands, Western Australia, Australia
Full record on ClinicalTrials.gov
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