Non-invasive Nerve Stimulation and Cognitive Training to Improve Cognitive Performance in Healthy Older Adults

Completed · Not applicable · Has a placebo group

Conditions studied: Aging

In brief

Decline in brain health and associated loss of cognitive function in healthy aging decreases quality of life.We need better tools to both enhance brain health and improve cognitive performance in healthy brain aging so that it can be delayed, reduced, or even reversed. The present proposal is designed to evaluate the pairing of cognitive training with a non-invasive neurostimulation technology that has shown promise in both increasing neuroplasticity and in enhancing cognitive performance, transcutaneous vagal nerve stimulation (tVNS).

Key facts

Study ID

NCT04276805

Run by

University of Florida

People needed

45

Starts

2020-11-17

Expected to finish

2024-09-27

Last updated by the study team

2026-07-27

Who can join

Age: 65 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy individuals willing to commit to study requirements

You may not qualify if…

• Neurological disorders to include traumatic brain injury.
• Evidence of dementia .
• Major psychiatric illness
• Unstable and chronic medical conditions.
• MRI contraindications (e.g., pregnancy, claustrophobia, metal implants that are contraindicated for MRI).
• Physical impairment precluding motor response or lying still or walking
• Hearing or vision deficits that will not allow for completion of assessments

Where it is running

• University of Arizona — Tucson, Arizona, United States
• University of Florida — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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