Study of PRP in Women With Evidence of Diminished Ovarian Reserve

Completed · Not applicable

Conditions studied: Diminished Ovarian Reserve, Ovarian Failure

In brief

The hypothesis of the study is that ovaries of women with a history of poor response to ovulation induction may benefit from exposure to growth factors known to be present in Platelet Rich Plasma (PRP). Since even ovaries from women with poor response still contain primordial follicles (which, however, no longer undergo recruitment), it is hoped that PRP injections into ovaries will activate follicular recruitment pathways and, subsequently, result in follicle growth. Should such growth be observed, follicles will be supported with routine daily gonadotropin stimulation until hCG trigger.

Key facts

Study ID

NCT04275700

Run by

Center for Human Reproduction

People needed

80

Starts

2018-10-01

Expected to finish

2024-09-01

Last updated by the study team

2025-05-07

Who can join

Age: 21 and older, up to 52. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women with failure to respond well to ovulation induction by having fewer than 1 cleavage stage embryo in response to past ovulation induction who do not qualify for the PRP4POI study
• Age 54 years and under.
• FSH > 12
• AMH < 1.1
• -No Aspirin or Motrin for one week before treatment

You may not qualify if…

• Age > 54 years
• Marked thrombocytopenia
• Blood diseases
• Hypofibrinogenemia
• Hemodynamic instability
• Anticoagulant or antiaggregant treatment
• Oncological diseases (specially, skeletal system and blood)
• Sepsis
• Acute and chronic infectious diseases
• Autoimmune diseases, for example, lupus erythematosus, etc.
• Relative contraindications for PRP
• Chronic liver diseases in the exacerbation phase
• Chronic intoxication against the background of long-term use of alcohol, addictive drugs, an administration of potent medications
• Use of steroidal anti-inflammatory drugs in less than 2 days before drawing the blood, an injection of corticosteroids in little less than 2 weeks before the procedure
• Pregnancy
• Inflammatory skin diseases, chronic dermatosis in the exacerbation phase, for example, psoriasis, atopic eczema, etc.

Where it is running

• Center For Human Reproduction — New York, New York, United States

Full record on ClinicalTrials.gov

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