The Hypotensive Effects of Home-Based Isometric Handgrip Training in Older Adults With Pre-Hypertension and Hypertension - The HoldAge Trial
Completed · Not applicable
Conditions studied: Hypertension, Pre-Hypertension
In brief
New data suggests that isometric handgrip training (IHT) might become a novel tool in the treatment of hypertension. The main purpose of this research project is to evaluate the effects of home-based IHT on ambulatory blood pressure in older adults with pre-hypertension and hypertension. Eighty-four older adults with pre-hypertension and hypertension will be randomly distributed to one of three groups: home-based IHT, home-based aerobic exercise training (AET), or attention-control group (CON). Each intervention will have a total duration of 8 weeks. At baseline and after completing the intervention, patients will undergo the following evaluations: 24-hour ambulatory blood pressure, cardiorespiratory fitness, endothelial function, damage and repair, arterial stiffness, inflammatory biomarkers, autonomic function, physical activity levels, dietary intake and quality of life. A qualitative analysis will also be applied to enhance the understanding of the efficacy of this intervention from the patient's perspective.
Key facts
- Study ID
- NCT04275037
- Run by
- University Institute of Maia
- People needed
- 84
- Starts
- 2021-04-12
- Expected to finish
- 2023-01-30
- Last updated by the study team
- 2023-05-22
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Secondary Hypertension
- Target Organ Damage
- Coronary Artery Disease
- Heart Failure
- Any Previous Cardiovascular Event
- Peripheral Artery Disease
- Renal Failure
- Chronic Obstructive Pulmonary Disease
- Insulin Dependent Diabetes
- Change of Antihypertensive Medication in the Past 4 Weeks Before Inclusion in the Study
- Smokers
- Those Participating in Regular Physical Activity
Where it is running
- University of Connecticut — Storrs, Connecticut, United States
- Unidade de Saúde Familiar de Santa Joana — Santa Joana, Aveiro, Aveiro District, Portugal
- University Institute of Maia — Maia, Porto District, Portugal
- Hypertension Unit, Hospital Pedro Hispano, ULS, Matosinhos, Portugal — Matosinhos Municipality, Porto District, Portugal
- Hospital Infante D. Pedro, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal — Aveiro, Portugal
- Institute of Biomedicine — Aveiro, Portugal
- University of Aveiro — Aveiro, Portugal
- Unidade de Saúde Familiar Serzedelo — Guimarães, Portugal
- CINTESIS, Faculty of Medicine, Porto, Portugal — Porto, Portugal
- Reserach Center in Sports Sciences, Health Sciences and Human Development — Vila Real, Portugal
Full record on ClinicalTrials.gov
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