Tessa Jowell BRAIN MATRIX - Platform Study

Recruiting now

Conditions studied: Glioma

In brief

The main aim of the Tessa Jowell BRAIN MATRIX - Platform Study is to more precisely determine the exact type of tumour patients have by developing the essential infrastructure to provide rapid and accurate molecular diagnosis. A large network of clinical hubs across the United Kingdom, with expertise in managing patients with brain tumours, will be developed. Once established this infrastructure will facilitate the rapid introduction of clinical trials testing targeted therapies tailored to the genetic changes of an individual's tumour.

Key facts

Study ID

NCT04274283

Run by

University of Birmingham

People needed

1000

Starts

2020-11-24

Expected to finish

2028-02-01

Last updated by the study team

2026-05-05

Who can join

Age: 16 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Newly diagnosed suspected WHO Grade 2-4 glioma, (as evidenced radiologically) AND suitable for a diagnostic or therapeutic surgical procedure resulting in a tumour sample matched to a blood sample.
• Patients with progression with known WHO Grade 2-4 glioma (those with available frozen tumour will be prioritised for detailed genomic analysis).
• Valid written informed consent for the study.

You may not qualify if…

• Primary spinal cord tumours
• Active treatment of other malignancy
• Contraindication to MRI
• Patients without standard of care imaging available

Where it is running

• Churchill Hospital, Oxford University Hospitals NHS Foundation Trust — Oxford, United Kingdom (enrolling)
• Freeman Hospital, The Newcastle upon Tyne Hospitals NHS Foundation Trust — Newcastle upon Tyne, United Kingdom (enrolling)
• Queen's Medical Centre, Nottingham University Hospitals NHS Trust — Nottingham, United Kingdom (enrolling)
• Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust — Birmingham, United Kingdom (enrolling)
• Velindre Cancer Centre, Velindre University NHS Trust — Cardiff, United Kingdom (enrolling)
• St James's University Hospital, Leeds Teaching Hospitals NHS Trust — Leeds, United Kingdom (enrolling)
• The Walton Centre, The Walton Centre NHS Foundation Trust — Liverpool, United Kingdom (enrolling)
• King's College Hospital, King's College Hospital NHS Foundation Trust — London, United Kingdom (enrolling)
• Charing Cross Hospital, Imperial College Healthcare NHS Trust — London, United Kingdom (enrolling)
• The Christie Hospital, The Christie NHS Foundation Trust — Manchester, United Kingdom (enrolling)
• Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust — Manchester, United Kingdom (enrolling)
• Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust — Cambridge, United Kingdom
• Queen Elizabeth Unviersity Hospital, NHS Greater Glasgow and Clyde Health Board — Glasgow, United Kingdom
• NHS Lothian — Edinburgh, United Kingdom

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.