Impact of Muscle Degeneration in Chronic Low Back Pain

Recruiting now

Conditions studied: Lumbar Spinal Stenosis, Lumbar Disc Herniation, Radiculopathy, Back Pain

In brief

Surgical interventions for the removal of intervertebral disc fragments or to enlarge a narrow spine canal are commonly performed worldwide and are considered efficient. Concomitant low back pain is not uncommon among patients with lumbar nerve compression and neurological symptoms. When present, controversy persists in the literature regarding its ideal management. Although neurological symptoms improve after decompressive surgery, the presence of residual chronic low back pain may worsen satisfaction scores and cause functional disability. The hypothesis of the present study is that the presence of atrophy of the paraspinal and trunk muscles predicts chronic low back pain after lumbar neural decompression. If confirmed, this finding will aid in better planning of physical rehabilitation strategies for this group of patients, as well as a clearer prediction regarding surgical treatment outcomes for patients and health professionals.

Key facts

Study ID

NCT04273828

Run by

Hospital Israelita Albert Einstein

People needed

168

Starts

2020-04-06

Expected to finish

2025-06-27

Last updated by the study team

2025-03-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• adults 18 years of age and older;
• with symptoms of lumbosacral neural compression (radiculopathy or neurogenic lameness);
• failed conservative treatment for at least 6 weeks;
• undergoing surgery for neural decompression (discectomy and / or foraminotomy and / or hemilaminectomy);
• with complete pre and postoperative medical records in all evaluations.

You may not qualify if…

• need for lumbar arthrodesis;
• deep infection requiring surgical cleaning;
• patients submitted to joint facet rhizotomy;
• active rheumatologic disease, including seronegative arthropathies.

Where it is running

• Hospital Israelita Albert Einstein — São Paulo, São Paulo, Brazil (enrolling)

Full record on ClinicalTrials.gov

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