Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome
Recruiting now · Not applicable
Conditions studied: Postural Tachycardia Syndrome, Orthostatic Intolerance
In brief
The mechanism behind postural orthostatic tachycardia syndrome (POTS) involves many causes including a sympathetic nervous system problem. Blood gases, like carbon dioxide (CO2), have an important effect on sympathetic activation. The purpose of this research study is to determine if higher CO2 levels have any effect in lowering heart rate and reducing POTS symptoms when upright/standing. The investigators are also searching for the ideal CO2 concentration to achieve the most effective response
Key facts
- Study ID
- NCT04271878
- Run by
- University of Calgary
- People needed
- 26
- Starts
- 2022-02-02
- Expected to finish
- 2030-12-31
- Last updated by the study team
- 2026-05-07
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Physician diagnosis of Postural Tachycardia Syndrome (POTS)
- Age 18-60 years
- Male and Female
- Non - smokers.
- Able and willing to provide informed consent.
- Ability to travel to Libin Cardiovascular Institute of Alberta Autonomic Testing Lab at the University of Calgary, Calgary, AB.
You may not qualify if…
- Overt cause for postural tachycardia, i.e., acute dehydration
- Participants with somatization or severe anxiety symptoms will be excluded
- Pregnant
- Inability to tolerate mask for the duration of the study
- Subjects who require portable oxygen at rest or with exercise
- Subjects with chronic heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath.
- Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies.
Where it is running
- University of Calgary — Calgary, Alberta, Canada (enrolling)
Full record on ClinicalTrials.gov
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