Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer

Running, not enrolling · Phase 3 · Has a placebo group

Conditions studied: Endometrial Neoplasms

In brief

A study to assess the efficacy and safety of durvalumab in combination with platinum-based chemotherapy (paclitaxel + carboplatin) followed by maintenance durvalumab with or without olaparib for patients with newly diagnosed advanced or recurrent endometrial cancer.

Key facts

Study ID

NCT04269200

Run by

AstraZeneca

People needed

805

Starts

2020-05-05

Expected to finish

2027-04-01

Last updated by the study team

2026-08-07

Who can join

Age: 18 and older, up to 150. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years at the time of screening and female.
• Histologically confirmed diagnosis of epithelial endometrial carcinoma. All histologies, including carcinosarcomas, will be allowed. Sarcomas will not be allowed.
• Patient must have endometrial cancer in one of the following categories:
• Newly diagnosed Stage III disease (measurable disease per RECIST 1.1 following surgery or diagnostic biopsy),
• Newly diagnosed Stage IV disease (with or without disease following surgery or diagnostic biopsy)
• Recurrence of disease (measurable or non-measurable disease per RECIST 1.1) where the potential for cure by surgery alone or in combination is poor.
• Naïve to first line systemic anti-cancer treatment. For patients with recurrent disease only, prior systemic anti-cancer treatment is allowed only if it was administered in the adjuvant setting and there is at least 12 months from date of last dose of systemic anti-cancer treatment administered to date of subsequent relapse
• FPPE tumor sample must be available for MMR evaluation.
• Has Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 within 7 days of starting study treatment.

You may not qualify if…

• History of leptomeningeal carcinomatosis.
• Brain metastases or spinal cord compression.
• Prior treatment with PARP inhibitors.
• Any prior exposure to immune-mediated therapy, including (but not limited to) other anti CTLA-4, anti-PD-1, anti-PD-L1, or anti-programmed-cell-death ligand 2 (anti-PD-L2) antibodies, excluding therapeutic anticancer vaccines.

Where it is running

• Research Site — Houston, Texas, United States
• Research Site — San Antonio, Texas, United States
• Research Site — Sugar Land, Texas, United States
• Research Site — Tyler, Texas, United States
• Research Site — Webster, Texas, United States
• Research Site — Fairfax, Virginia, United States
• Research Site — Norfolk, Virginia, United States
• Research Site — Seattle, Washington, United States
• Research Site — Morgantown, West Virginia, United States
• Research Site — Madison, Wisconsin, United States
• Research Site — Milwaukee, Wisconsin, United States
• Research Site — Clayton, Australia
• Research Site — Malvern, Australia
• Research Site — Melbourne, Australia
• Research Site — Nedlands, Australia
• Research Site — Sydney, Australia
• Research Site — Bruges, Belgium
• Research Site — Brussels, Belgium
• Research Site — Charleroi, Belgium
• Research Site — Ghent, Belgium
• Research Site — Hasselt, Belgium
• Research Site — Kortrijk, Belgium
• Research Site — Leuven, Belgium
• Research Site — Libramont-Chevigny, Belgium
• Research Site — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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