GPx Activity in Subjects With Aortic Stenosis Undergoing TAVR

Withdrawn before enrolling

Conditions studied: Glutathione Peroxidase Activity, Aortic Stenosis, Transcatheter Aortic Valve Replacement

In brief

The aim of this project is to investigate the association of glutathione peroxidase (GPx) and severe aortic stenosis (AS), as well as the impact of transcatheter aortic valve replacement (TAVR) on GPx activity post-procedure. The burden of oxidative stress will be determined by the measurement of GPx, superoxide dismutase (SOD) and lipoprotein A (Lp(a)). We hypothesize GPx activity is reduced in participants with severe AS vs control groups and GPx activity is to increase after TAVR is performed.

Key facts

Study ID

NCT04268160

Run by

University of Florida

People needed

0

Starts

2020-11-01

Expected to finish

2021-06-15

Last updated by the study team

2021-06-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age >18 years
• Patients with severe AS including participants with low flow, low gradient severe AS and paradoxical severe AS
• Patients meeting criteria for TAVR procedure

You may not qualify if…

• Previous aortic valve replacement (surgical or TAVR)
• Participants undergoing chemotherapy
• End stage liver disease/cirrhosis (liver produces GSH)

Where it is running

• University of Florida — Jacksonville, Florida, United States

Full record on ClinicalTrials.gov

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