Lifestyle Intervention for the Reduction of Breast Cancer Risk in Normal Weight Women

Running, not enrolling · Not applicable

Conditions studied: Breast Carcinoma

In brief

This trial studies how well a lifestyle intervention works in reducing breast cancer risk through changing body composition and decreasing inflammation in normal weight women. This trial may help researchers learn more about diet and exercise programs designed to decrease body fat in postmenopausal women who are of normal weight but have an elevated risk of breast cancer because of excess body fat.

Key facts

Study ID: NCT04267796
Run by: M.D. Anderson Cancer Center
People needed: 40
Starts: 2021-06-25
Expected to finish: 2026-07-01
Last updated by the study team: 2026-04-16

Who can join

Age: 50 and older, up to 69. Sex: female. Healthy volunteers: accepted.

You may qualify if…

Age 50-69 years old
Postmenopausal woman (absence of menstruation for at least one year, or history of bilateral oophorectomy)
Self-reported height and weight indicating a BMI >= 18.5 and < 25 kg/m\^2
No contraindications to exercise (either no positive responses on the Physical Activity Readiness Questionnaire, or clearance from a health care provider certifying that the participant is healthy enough to exercise)
No history of invasive cancer, other than non-melanoma skin cancer
No history of renal disease
Able to walk without an assistive device
Not within 3 months of major surgery
Able to speak/read/write in English
Has internet access on a computer or mobile device
A trunk fat mass >= 9.4 kg as indicated by a dual x-ray absorptiometry (DXA) scan
Height and weight indicating a BMI of >= 18.5 and < 25 kg/m\^2 verified at the screening visit

You may not qualify if…

MD Anderson employees that report to the principal investigator of this study
Participants that cannot engage in the exercise program for more than three weeks during the study period
Participants that are currently doing strength exercises that work all major muscle groups (defined as: participants who complete more than 16 repetitions per exercise in their current resistance training regimen, or who don't find their last 1-2 reps to be difficult in their current regimen, or who increase the weight in their current routine).

Where it is running

M D Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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