Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency Department

Completed · Phase 4 · Has a placebo group

Conditions studied: Depression, Depression Severe, Depression Acute, Depression and Suicide, Suicidal Ideation

In brief

The purpose of this study is to examine the effect of a low-dose ketamine infusion on depression symptoms within the Emergency Department (ED) visit, and healthcare utilization after leaving the ED, when administered in the ED for depression or suicidal ideation.

Key facts

Study ID

NCT04266288

Run by

MercyOne Des Moines Medical Center

People needed

29

Starts

2019-10-18

Expected to finish

2020-05-31

Last updated by the study team

2020-09-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults 18 years of age and older
• Presenting to the ED with a chief complaint of severe depression or suicidality, or presenting to the ED with any other chief complaint but answering "yes" to "Thoughts of harming/killing yourself?" during intake/triage

You may not qualify if…

• Acute mania or psychosis
• Enrollment in trial during a prior emergency department visit
• History of ketamine abuse or dependence
• Known hypersensitivity to ketamine
• Acute intoxication with any drug of abuse (including alcohol)
• Pregnancy or lactation
• Any condition that would place the patient at serious risk of harm from an increase in blood pressure (e.g. history of intracerebral hemorrhage, aneurysmal vascular disease, or arteriovenous malformation)
• Assessing provider does not want to enroll patient for any other reason, based on their clinical judgement

Where it is running

• MercyOne Des Moines Medical Center — Des Moines, Iowa, United States

Full record on ClinicalTrials.gov

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