Bowel Function After Minimally Invasive Hysterectomy

Completed · Phase 4

Conditions studied: Constipation

In brief

Postoperative constipation affects up to a third of women undergoing minimally invasive (MIS) gynecologic surgery and is a major source of anxiety and discomfort. The average time to first bowel movement after gynecologic surgery is about 2 to 4 days and some factors responsible for this include anesthesia inhibitory effect on gastrointestinal motility, opioid pain medication use, chronic nonsteroidal anti-inflammatory drugs (NSAID) use and anatomic manipulation. There are no established regimens to manage postoperative constipation after minimally invasive gynecologic surgery. Two studies evaluating the implementation of postoperative bowel regimen with polyethylene glycol (PEG) and with Senna and Docusate found no significant impact on postoperative bowel function. There have been no studies looking at the effect of preoperative bowel regimens on postoperative bowel function. The purpose of this study is to evaluate postoperative bowel function after minimally invasive hysterectomy in women receiving a preoperative 10-day bowel regimen of PEG daily.

Key facts

Study ID

NCT04263896

Run by

University of Chicago

People needed

97

Starts

2019-08-28

Expected to finish

2025-06-09

Last updated by the study team

2025-08-19

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Any woman ≥ 18 years of age undergoing a minimally invasive hysterectomy (Laparoscopic, robotic, vaginal)
• Able to understand the consenting process and willing to participate in study

You may not qualify if…

• Planned laparotomy
• Emergent surgery
• Regular preoperative use of PEG 3350, laxatives, enemas or suppositories
• Planned bowel surgery
• Presence of colostomy
• Inability to consent
• Medical problems as follows:
• Chronic Kidney Disease (Cr: > 1.2 mg/dL)
• Insulin-Dependent Diabetes Mellitus
• Cardiac disease
• Gastric ulcers
• Difficulty swallowing or esophageal stricture
• Persistent nausea or vomiting
• Signs or symptoms of a small bowel obstruction

Where it is running

• University of Chicago Medicine — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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