NFL LONG Prospective Study

Running, not enrolling · Phase 1

Conditions studied: Concussion, Brain

In brief

The purpose of this 5-year prospective research study is to characterize the association between concussions, sub-concussive exposure, and long-term neurologic health outcomes in former NFL players. To achieve the study aims, the investigators will conduct detailed research visits that include clinical outcome assessments, blood-based biomarkers, advanced magnetic resonance imaging (MRI), positron emission tomography (PET) using investigational tracers and genetic testing. Ultimately, the goal of this study is to translate the findings from this study into clinical, interventional studies for at risk former NFL players.

Key facts

Study ID

NCT04263337

Run by

University of North Carolina, Chapel Hill

People needed

250

Starts

2020-03-12

Expected to finish

2028-08-01

Last updated by the study team

2026-04-22

Who can join

Age: 50 and older, up to 70. Sex: male. Healthy volunteers: accepted.

You may not qualify if…

• Any contraindications to MRI, PET, or biological study procedures
• History of Moderate or Severe TBI
• Current primary Axis I diagnosis of Psychotic Disorder
• History or clinical suspicion of other conditions (e.g., epilepsy, stroke, dementia) known to cause cognitive dysfunction
• Diagnosis /associated treatment that would preclude participation in full study protocol (e.g., terminal cancer)

Where it is running

• Boston Children's Hospital — Waltham, Massachusetts, United States
• University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
• Medical College of Wisconsin — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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