Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure

Recruiting now

Conditions studied: Cardiotoxicity, Pediatric Cancer, Heart Failure

In brief

Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to the development of significant changes in heart function are limited. This study will focus on imaging markers of cardiac injury and dysfunction with the goal of developing improved diagnostic tests and treatment strategies.

Key facts

Study ID

NCT04262830

Run by

Hari Narayan

People needed

150

Starts

2019-09-30

Expected to finish

2030-09-30

Last updated by the study team

2025-01-28

Who can join

Age: 13 and older, up to 39. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• English and Spanish speaking male and female subjects, ages 13-39 years old
• Diagnosis of cancer at age <22 years
• Previously treated with anthracyline therapy for cancer, with diagnosis at least two years prior.

You may not qualify if…

• Patients who have a contraindication to cardiac MRI, including the presence of non-MRI compatible metallic implants.
• Medical, psychiatric, and/or social disorder that would prevent successful completion of planned study testing or would preclude the subject from undergoing the cardiac MRI without anesthesia.
• Patients with a history of congenital heart disease (more significant than a history of patent foramen ovale or patent ductus arteriosus).
• Pregnancy (at the time of enrollment).

Where it is running

• Rady Children's Hospital — San Diego, California, United States (enrolling)

Full record on ClinicalTrials.gov

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