Predominant Sensitizations to Single Bee Venom Allergens as a Risk Factor for Therapy Failure
Recruiting now
Conditions studied: Bee Venom Allergy
In brief
Venom immunotherapy (VIT) is an established treatment for Hymenoptera venom allergy and provides long-term protection from further generalized reactions in almost all patients. However, it is still unclear why bee VIT is less effective than vespid VIT. The preliminary data show that not only predominant Api m 10 sensitization but also other predominant sensitizations may be relevant as risk factors for treatment failure. Interestingly, all patients with a predominant Api m 10 sensitization who received bee VIT with a venom preparation with a supposed lack of Api m 10 tolerated sting challenges. Therefore, a multicenter study with a sufficient number of patients with treatment failure is urgently required, to clarify if predominant sensitization to a bee venom allergen is a risk factor for treatment failure. If predominant sensitization is a risk factor and caused by underrepresented components in bee venom preparations used for VIT, bee venom preparations may be optimized in the future and patients would benefit from a more effective VIT.
Key facts
- Study ID
- NCT04259359
- Run by
- Medical University of Graz
- People needed
- 266
- Starts
- 2019-05-02
- Expected to finish
- 2026-03-01
- Last updated by the study team
- 2025-12-08
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Legally competent male and female subjects aged from 18 to 70 years with a history of a systemic anaphylactic sting reaction (≥ grade I according to the classification of Ring and Messmer) after bee stings, who will receive bee venom immunotherapy
You may not qualify if…
- Contraindications to VIT
Where it is running
- Department of Dermatology and Venerology, Medical University of Graz — Graz, Austria (enrolling)
- Elbe Klinikum Buxtehude — Buxtehude, Germany (enrolling)
- Hospital Universitario de Castellón — Castellon, Spain (enrolling)
Full record on ClinicalTrials.gov
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