Multidimensional System to Dynamically Predict Graft Survival After Kidney Transplantation
Completed
Conditions studied: Kidney Transplant Failure
In brief
The incidence of end stage renal disease (ESRD) is rapidly increasing, now affecting an estimated 7.4 million people worldwide. Numerous parameters such as demographic, clinical and functional factors drive the deterioration of the kidney, ultimately leading to ESRD. Although some ESRD prediction models have been derived in the past years, none of these models are dynamic: they do not integrate the repeated measurements recorded throughout individuals' follow-up. As highlighted in several studies, kidney function repeated measurements (i.e., trajectories) are highly associated with graft survival after kidney transplantation. The investigators made the hypothesis that these trajectories may bring relevant information in the context of graft survival risk prediction model. Hence, combining these trajectories with standard graft survival risk factors may enhance prediction performance. This could permit to derive a robust tool that could be updated over time by continuously capturing patient' personal evolution.
Key facts
- Study ID
- NCT04258891
- Run by
- Paris Translational Research Center for Organ Transplantation
- People needed
- 14000
- Starts
- 2004-01-01
- Expected to finish
- 2020-06-30
- Last updated by the study team
- 2020-09-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Kidney recipients transplanted after 2004
- Kidney recipients over 18 years of age
- Kidney recipients with at least two estimated glomerular filtration rate and proteinuria measurements after transplantation
You may not qualify if…
- Combined transplantation
Where it is running
- Department of Medicine, Division of Nephrology, Comprehensive Transplant Center, Cedars Sinai Medical Center — Los Angeles, California, United States
- Division of Transplantation, Department of Surgery, Feinberg School of Medicine, Northwestern University — Chicago, Illinois, United States
- Department of Surgery, Johns Hopkins University School of Medicine — Baltimore, Maryland, United States
- William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic — Rochester, Minnesota, United States
- Albert Einstein College of Medicine, Renal Division Montefiore Medical Center, Kidney Transplantation Program — New York, New York, United States
- Unidad de Trasplante Renopáncreas, Centro de Educación Médica e Investigaciones Clínicas — Buenos Aires, Argentina
- Universidade Federal de São Paulo, Hospital do Rim, Escola Paulista de Medicina — São Paulo, Brazil
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Renal Transplantation Service — São Paulo, Brazil
- Clinica Alemana de Santiago — Santiago, Chile
- Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, School od Medicine University of Zagreb — Zagreb, Croatia
- Department of Nephrology, Centre Hospitalier Universitaire de Montpellier — Montpellier, France
- Nephrology Dialysis Transplantation Department, University of Lorraine, Centre Hospitalier Universitaire de Nancy — Nancy, France
- Kidney Transplant Department, Saint-Louis Hospital, Assistance Publique - Hôpitaux de Paris — Paris, France
- Kidney Transplant Department, Necker Hospital, Assistance Publique - Hôpitaux de Paris — Paris, France
- Department of Transplantation, Nephrology and Clinical Immunology, Hôpital Foch — Suresnes, France
- Department of Nephrology and Organ Transplantation, Centre Hospitalier Universitaire Rangueil — Toulouse, France
- Bretonneau Hospital, Nephrology and Immunology Department — Tours, France
- Department of Nephrology, Hospital del Mar — Barcelona, Spain
Full record on ClinicalTrials.gov
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