OCT in Fuchs' Dystrophy

Recruiting now

Conditions studied: Fuchs Dystrophy, Pseudophakic Bullous Keratopathy

In brief

This is an observational study using optical coherence tomography (OCT) technology to quantify corneal edema in Fuchs' endothelial dystrophy and predict refractive shift from resolving corneal edema after surgical treatments.

Key facts

Study ID

NCT04258787

Run by

Oregon Health and Science University

People needed

60

Starts

2020-06-26

Expected to finish

2028-06-01

Last updated by the study team

2025-09-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Damaged or diseased corneal endothelium from Fuchs' or PBK
• Willingness to commit to required study visits

You may not qualify if…

• Prior Endothelial Keratoplasty (EK) or any other surgery except uncomplicated cataract surgery
• Presence of a condition that increases the probability for treatment failure (e.g., heavily vascularized cornea, uncontrolled uveitis)
• Other primary endothelial dysfunction conditions (e.g., posterior polymorphous corneal dystrophy and congenital hereditary corneal dystrophy, iridocorneal endothelial syndrome)
• Central sub-epithelial or stromal scarring that could impact post-operative clarity assessment
• Peripheral anterior synechiae in the angle greater than 3 clock hours
• Hypotony
• Uncontrolled glaucoma
• Visually significant optic nerve or macular pathology

Where it is running

• Oregon Health & Science University — Portland, Oregon, United States (enrolling)

Full record on ClinicalTrials.gov

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