Dose Escalation Study of PF-07209326 in Healthy Participants and Participants With Sickle Cell Disease
Completed · Phase 1 · Has a placebo group
Conditions studied: Healthy, Sickle Cell Anemia
In brief
This Phase 1 first-in-human, first-in-patient, single ascending dose and multiple dose study will be a randomized, double-blind, placebo-controlled investigation of the safety, tolerability, and pharmacokinetics of PF-07209326 in healthy participants and participants with sickle cell disease.
Key facts
- Study ID
- NCT04255875
- Run by
- Pfizer
- People needed
- 52
- Starts
- 2020-02-05
- Expected to finish
- 2023-07-07
- Last updated by the study team
- 2026-06-15
Who can join
Age: 16 and older, up to 70. Sex: any. Healthy volunteers: accepted.
Where it is running
- New Haven Clinical Research Unit — New Haven, Connecticut, United States
- Howard University College of Medicine — Washington D.C., District of Columbia, United States
- Golisano Children's Hospital of Southwest Florida — Fort Myers, Florida, United States
- Lee Health - Golisano Children's Hospital of Southwest Florida — Fort Myers, Florida, United States
- Foundation for Sickle Cell Disease Research — Hollywood, Florida, United States
- Foundation for Sickle Cell Disease Research — Hollywood, Florida, United States
- Children's Healthcare of Atlanta - Egleston Hospital-Aflac Cancer and Blood Disorders Center — Atlanta, Georgia, United States
- University of Illinois at Chicago Clinical Research Center — Chicago, Illinois, United States
- University of Illinois at Chicago — Chicago, Illinois, United States
- Prism Research LLC dba Nucleus Network — Saint Paul, Minnesota, United States
- Columbia University Medical Center - Herbert Irving Pavilion — New York, New York, United States
- CUIMC Research Pharmacy — New York, New York, United States
- CUMC Research Pharmacy — New York, New York, United States
- UT Physicians Comprehensive Sickle Cell Center Houston — Houston, Texas, United States
- Memorial Hermann clinical research unit — Houston, Texas, United States
- UT Physicians Comprehensive Sickle Cell Center Houston — Houston, Texas, United States
Full record on ClinicalTrials.gov
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