Understanding GWI: Integrative Modeling

Status unconfirmed · Phase 1

Conditions studied: Gulf War Illness, Persian Gulf Syndrome, Occupational Diseases

In brief

The investigator proposes to perform a Phase I study assessing safety, efficacy, and biomarker response to the therapeutic interventions of Etanercept followed by mifepristone for veterans with Gulf War Illness. The investigator will conduct and repeat the exercise challenge before treatment and on therapy to assess the impact of the interventions on homeostatic regulation and the dynamic model identified in prior studies.

Key facts

Study ID

NCT04255498

Run by

South Florida Veterans Affairs Foundation for Research and Education

People needed

20

Starts

2017-10-30

Expected to finish

2020-08-30

Last updated by the study team

2020-02-05

Who can join

Age: 40 and older, up to 70. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Male Veterans who were deployed in 1990 -1991 Gulf War.
• Veterans who currently meet the Kansas Gulf War Study Case Definition for Gulf War Illness.
• Veterans who were in good health based on medical history prior to 1990.
• Veterans who are between 40 to 70 years old
• Veterans who currently do not have exclusionary diagnoses that could reasonably explain the symptoms of their fatiguing illness and their severity.

You may not qualify if…

• Major depression with psychotic or melancholic features
• Schizophrenia
• Bipolar disorder
• Delusional disorders
• Dementias of any type
• History or current alcohol abuse
• History or current drug abuse
• Organ failure
• Transplant
• Defined rheumatologic
• Inflammatory disorders
• HIV
• Hepatitis B and C
• Primary sleep disorders
• Steroids
• Immunosuppressives
• Medications that impact immune function such as Enbrel or Methotrexate
• Tuberculosis or past history of tuberculosis exposure, as documented by PPD positivity

Where it is running

• Miami VA Healthcare System — Miami, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.