Choline Source, Gut Microbiota and Trimethylamine-N-oxide Response

Completed · Not applicable

Conditions studied: Metabolism

In brief

The purpose of this research is to determine the production of trimethylamine-N-oxide (TMAO) from different forms of choline and whether this response is modified by the gut microbiota composition.

Key facts

Study ID

NCT04255368

Run by

Utah State University

People needed

44

Starts

2017-11-09

Expected to finish

2020-07-25

Last updated by the study team

2020-11-04

Who can join

Age: 21 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy men and women of any race or ethnicity
• Age 21-50 y
• BMI 20-24.9 kg/m2 or BMI 30-39.9 kg/m2

You may not qualify if…

• Age > 50 y
• BMI outside of the normal-weight or obese range (BMI < 20 kg/m2; BMI 25-29.9 kg/m2; or BMI > or = 40 kg/m2)
• Pregnant or planning to become pregnant during the course of the study; currently breastfeeding (females)
• Vegetarians
• Smokers or recreational drug users
• Individuals with gastrointestinal diseases or complaints, chronic illnesses or other metabolic diseases (including trimethylaminuria)
• Individuals who have taken antibiotics within the past 2 months
• Individuals who are not willing to discontinue pre- and probiotics and dietary supplements for the time leading up to 2 months before the study and during the study

Where it is running

• Center for Human Nutrition Studies Clinic, Utah State University — Logan, Utah, United States

Full record on ClinicalTrials.gov

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