Impact of Estradiol on Endothelial Function in Peri-Menopausal Women

Running, not enrolling · Phase 4 · Has a placebo group

Conditions studied: Perimenopause, Vasodilation, Estrogen

In brief

The purpose of this study is to identify the impact of estradiol (E2) on the mechanisms that regulate vascular endothelial function in peri-menopausal (PERI) women. This study is the first step in understanding factors contributing to endothelial dysfunction in women with advancing reproductive age and in response to E2 administration.

Key facts

Study ID: NCT04255160
Run by: University of Delaware
People needed: 80
Starts: 2020-10-01
Expected to finish: 2026-10-31
Last updated by the study team: 2026-04-29

Who can join

Age: 40 and older, up to 58. Sex: female. Healthy volunteers: accepted.

You may qualify if…

Peri-menopausal women between 40-58 years of age with variable cycles as defined by increase in cycle length of greater than 7 days within ten consecutive cycles, or amenorrhea for more than 2 months, but less than 12 months.

You may not qualify if…

Women who are pregnant, planning on becoming pregnant, or are breast feeding;
Women who have a history of cardiovascular disease, blood clots (e.g, pulmonary embolism or deep vein thrombosis), stroke, cancer, or liver disease;
Women who have a body mass index less than 18 or greater than 35kg/m2;
Women who use tobacco products;
Women who's blood pressure is greater than 140/90 mmHg, have been diagnosed by a physician with hypertension or are taking medication for high blood pressure;
Women who have a neurological disease, or diabetes;
Women who have had a hysterectomy or have used hormones (birth control or hormone replacement) within the past 3 months;
Women who have a latex allergy.

Where it is running

University of Delaware — Newark, Delaware, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.