A Safety Study of SEA-TGT (SGN-TGT) in Advanced Cancer
Stopped early · Phase 1
Conditions studied: Non-small Cell Lung Cancer, Gastric Carcinoma, Gastroesophageal Junction Carcinoma, Classical Hodgkin Lymphoma, Diffuse Large B-cell Lymphoma, Peripheral T-cell Lymphoma, Cutaneous Melanoma, Head and Neck Squamous Cell Carcinoma, Bladder Cancer, Ovarian Cancer, Triple Negative Breast Cancer, Cervical Cancer
In brief
This trial will look at a drug called SEA-TGT (also known as SGN-TGT) to find out whether it is safe for patients with solid tumors and lymphomas. It will study SEA-TGT to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study whether SEA-TGT works to treat solid tumors and lymphomas. The study will have four parts. Part A of the study will find out how much SEA-TGT should be given to patients. Part B will use the dose found in Part A to find out how safe SEA-TGT is and if it works to treat solid tumors and lymphomas. Part C will study how well SEA-TGT with sasanlimab works to treat solid tumors. Part D will study how well SEA-TGT with brentuximab vedotin works to treat classical Hodgkin lymphoma (cHL).
Key facts
- Study ID
- NCT04254107
- Run by
- Seagen Inc.
- People needed
- 133
- Starts
- 2020-05-29
- Expected to finish
- 2023-12-01
- Last updated by the study team
- 2025-02-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States
- Arizona Oncology Associates, PC - HOPE — Tucson, Arizona, United States
- City of Hope — Duarte, California, United States
- California Research Institute — Los Angeles, California, United States
- University of California, San Francisco | HDFCCC - Hematopoietic Malignancies — San Francisco, California, United States
- Yale Cancer Center — New Haven, Connecticut, United States
- Johns Hopkins Medical Center — Baltimore, Maryland, United States
- Maryland Oncology Hematology, P.A. — Rockville, Maryland, United States
- University of Michigan Comprehensive Cancer Center — Ann Arbor, Michigan, United States
- Minnesota Oncology Hematology P.A. — Minneapolis, Minnesota, United States
- Mayo Clinic Rochester — Rochester, Minnesota, United States
- University of Mississippi Medical Center — Jackson, Mississippi, United States
- Weill Cornell Medicine — New York, New York, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- Wake Forest Baptist Medical Center / Wake Forest University — Winston-Salem, North Carolina, United States
- University of Cincinnati Cancer Institute — Cincinnati, Ohio, United States
- Providence Portland Medical Center — Portland, Oregon, United States
- University of Pittsburgh Medical Center (UPMC)/Hillman Cancer Center — Pittsburgh, Pennsylvania, United States
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
- Texas Oncology - Austin Midtown — Austin, Texas, United States
- Texas Oncology - Baylor Sammons Cancer Center — Dallas, Texas, United States
- MD Anderson Cancer Center / University of Texas — Houston, Texas, United States
- Texas Oncology - Northeast Texas — Tyler, Texas, United States
- Oncology and Hematology Assoc of SW VA DBA Blue Ridge Cancer Care — Blacksburg, Virginia, United States
- Virginia Cancer Specialists, PC — Fairfax, Virginia, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.