Sleep-disordered Breathing in Infants With Myelomeningocele

Completed

Conditions studied: Sleep-disordered Breathing, Myelomeningocele

In brief

This study aims to determine whether the risk for sleep-disordered breathing in infants with myelomeningocele (a severe form of spina bifida) differs among those who underwent fetal vs. postnatal surgery, and to examine the link between sleep-disordered breathing and neurodevelopment.

Key facts

Study ID

NCT04251806

Run by

University of Michigan

People needed

173

Starts

2020-07-21

Expected to finish

2026-05-19

Last updated by the study team

2026-05-27

Who can join

Age: any, up to 2. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• born at <30 weeks gestation
• congenital anomalies that would predispose to sleep-disordered breathing (e.g. micrognathia)
• confirmed or suspected genetic syndromes that alter developmental outcomes

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• Children's Hospital Colorado — Aurora, Colorado, United States
• Mott Children's Hospital — Ann Arbor, Michigan, United States
• Children's Minnesota — Minneapolis, Minnesota, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Washington University — St Louis, Missouri, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• University of Texas-Houston — Houston, Texas, United States

Full record on ClinicalTrials.gov

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