The Use of Transcranial Focused Ultrasound for the Treatment of Neurodegenerative Dementias

Status unconfirmed · Not applicable

Conditions studied: Mild Cognitive Impairment, Mild Dementia, Parkinson Disease, Alzheimer Disease

In brief

The purpose of this open label study is to evaluate longer term tolerability and early efficacy of transcranial ultrasound in the treatment of patients with mild cognitive impairment or dementia.

Key facts

Study ID

NCT04250376

Run by

Neurological Associates of West Los Angeles

People needed

100

Starts

2017-11-27

Expected to finish

2025-01-01

Last updated by the study team

2023-03-24

Who can join

Age: 45 and older, up to 93. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• CDR stage of at least 0.5 (mild cognitive impairment)
• At least one pathognomic imaging biomarker of a neurodegenerative process.

You may not qualify if…

• Cognitive decline clearly related to an acute illness
• Subjects unable to give informed consent
• Subjects with scalp rash or open wounds on the scalp (for example from treatment of squamous cell cancer)
• Advanced terminal illness
• Advanced kidney, pulmonary, cardiac or liver failure
• Subjects who would not be able to lay down without excessive movement in a calm environment sufficiently long enough to be able to achieve sleep
• Subjects with major depressive disorder
• Subjects with vascular causes of dementia

Where it is running

• Neurological Associates of West LA — Santa Monica, California, United States

Full record on ClinicalTrials.gov

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