Induced Membrane Properties in Children and Adults

Recruiting now · Not applicable

Conditions studied: Bone Loss, Surgery

In brief

Bone reconstruction in critical sized defect (CSD) remains a real challenge in orthopedic surgery in children and adults. The Masquelet technique is an innovative therapeutic technique, which offers a bone reconstruction in two steps, by the formation of an induced membrane (IM) around a polymethylmethacrylate (PMMA) spacer placed into the bone defect. After, PMMA removal, the cavity is filled with corticocancellous graft allowing bone healing. Up to date, all angiogenesis and osteogenic properties of IM remain unknown. The purpose of this study is to characterize angiogenesis and osteogenic properties of IM in children and adults.

Key facts

Study ID

NCT04246944

Run by

Centre Hospitalier Universitaire, Amiens

People needed

50

Starts

2019-05-23

Expected to finish

2030-01-01

Last updated by the study team

2025-06-08

Who can join

Age: 1 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All patients treated at CHU Amiens-Picardie for bone critical sized defect treated using the induced membrane reconstruction technique.
• patients from 9 months to 60 years old

You may not qualify if…

• Patients managed by another reconstruction technique for critical sized defect
• Patients under guardianship, curators or deprived of liberty.
• Pregnant and nursing women.
• Patients who refused to participate in the study and to sign informed consent.

Where it is running

• CHU Amiens — Amiens, France (enrolling)

Full record on ClinicalTrials.gov

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