A Study of HD-tDCS and Cognitive Training to Improve Cognitive Function in MCI

Completed · Not applicable · Has a placebo group

Conditions studied: Mild Cognitive Impairment, Memory Disorders, Memory Loss

In brief

The primary objective of this project is to assess the feasibility of multi-field, extended HD-tDCS (MFE-HD-tDCS) with simultaneous computerized CT as a viable intervention to improve cognitive function in patients with MCI. This double-blinded, randomized pilot clinical trial of repetitive daily HD-tDCS/sham HD-tDCS, administered in combination with CT to subjects with MCI in 3 monthly blocks of 5 daily sessions for a total of 15 sessions will enroll 8 participants.

Key facts

Study ID

NCT04246164

Run by

Medical College of Wisconsin

People needed

8

Starts

2021-01-25

Expected to finish

2023-02-23

Last updated by the study team

2026-04-23

Who can join

Age: 50 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥50-90 years
• Willing and able to undergo all procedures
• Retains decisional capacity at initial visit
• Meets criteria for MCI, amnestic type (Petersen, 2004).

You may not qualify if…

• Significant kidney injury requiring hemodialysis
• Automatic Internal Cardiac Defibrillator (AICD) or Pacemaker
• Significant congestive heart failure
• History of clinically significant ischemic or hemorrhagic stroke, or lacune or infarct considered by radiologist likely to cause or contribute significantly to cognitive symptoms
• History of thalamic lacunar stroke
• Modified Hachinski Ischemia Score >4 points
• History of seizure disorder requiring medication
• History of brain surgery (for seizure disorder, aneurysms, or benign/malignant tumor)
• History of HIV/AIDS
• Severe untreated obstructive sleep apnea
• Greater than three servings alcohol daily or illicit drug use
• Major neurologic disorders other than dementia (e.g., MS, ALS)
• Schizophrenia, bipolar disorder, other serious mental illnesses
• Other significant medical conditions at investigators' discretion
• Pregnancy
• Lack of study partner (Participants are allowed to find a new study partner if the original study partner withdraws)

Where it is running

• The Medical College of Wisconsin — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.