Trifecta-Kidney cfDNA-MMDx Study

Recruiting now

Conditions studied: Kidney Transplant Rejection

In brief

Demonstrate the relationship between DD-cfDNA levels and HLA antibodies in blood, and the Molecular Microscope® (MMDx) Diagnostic System results in indication biopsies.

Key facts

Study ID

NCT04239703

Run by

University of Alberta

People needed

300

Starts

2019-12-01

Expected to finish

2029-12-01

Last updated by the study team

2026-06-02

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All kidney transplant recipients undergoing a kidney biopsy for clinical indications, as determined by their physician or surgeon, will be eligible to enroll in the study.

You may not qualify if…

• Patients will be excluded from the study if they decline participation or are unable to give informed consent or multiple organ recipients.

Where it is running

• Tampa General Hospital — Tampa, Florida, United States (enrolling)
• University of Maryland School of Medicine — Baltimore, Maryland, United States (enrolling)
• The Johns Hopkins University, School of Medicine — Baltimore, Maryland, United States (enrolling)
• Pomeranian Medical University, Samodzielny Publiczny Woj. Szpital Zespolony, Oddzial Nefrologii i Transplantacji Nerek — Szczecin, Poland (enrolling)
• Medical University of Warsaw, Department of Transplantation Medicine, Nephrology and Internal Diseases — Warsaw, Poland (enrolling)
• Transplant Medicine & Nephrology Clinic, Medical University of Warsaw — Warsaw, Poland (enrolling)
• Wroclaw Medical University, Department of Nephrology and Transplantation Medicine — Wroclaw, Poland (enrolling)
• Department of Nephrology, University Medical Centre — Ljubljana, Slovenia (enrolling)
• Henry Ford Hospital — Detroit, Michigan, United States (enrolling)
• Barnes-Jewish Hospital, Washington University at St. Louis — St Louis, Missouri, United States (enrolling)
• University Hospitals Cleveland Medical Ctr. — Cleveland, Ohio, United States (enrolling)
• Cleveland Clinic — Cleveland, Ohio, United States (enrolling)
• Intermountain Transplant Services — Murray, Utah, United States (enrolling)
• Virginia Commonwealth University Medical Center — Richmond, Virginia, United States (enrolling)
• Division of Nephrology & UW Organ Transplant Center University of Washington — Seattle, Washington, United States (enrolling)
• Department of Nephrology, The Royal Melbourne Hospital 1 South East — Melbourne, Australia (enrolling)
• University of Alberta, Department of Medicine — Edmonton, Alberta, Canada (enrolling)
• ST. Paul's Hospital, 6A Providence Building, 1081 Burrard Street — Vancouver, British Columbia, Canada (enrolling)
• University Hospital Merkur Renal Division — Zagreb, Croatia (enrolling)
• Institute for Clinical and Experimental Medicine (IKEM) — Prague, Czechia (enrolling)
• Charite-Medical University of Berlin Department of Nephrology — Berlin, Germany (enrolling)
• Centre of Nephrology, Vilnius University Hospital Santaros Klinikos — Vilnius, Lithuania (enrolling)
• Medical University of Gdańsk Klinika Nefrologii Transplantologii i Chorób Wewnętrznych — Gdansk, Poland (enrolling)
• Medical University of Silesia — Katowice, Poland (enrolling)
• Department of Transplantation and General Surgery, Wojewodzki Hospital — Poznan, Poland (enrolling)

Full record on ClinicalTrials.gov

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