Short Term Ketone Supplementation and Cardiometabolic Health
Completed · Not applicable · Has a placebo group
Conditions studied: Cardiovascular Risk Factor
In brief
The purpose of this research study is to determine if short-term consumption of a dietary ketone drink, which increases the blood circulation concentrations of beta-hydroxybutyrate, a ketone, affects blood vessel health and cognitive health in adults. Ketones are normally produced by the liver when people fast longer than 16-24 hours or eat a diet low in carbohydrates. Participants will be asked to randomly consume a dietary ketone drink and placebo (flavored water) for a 2-week period each in a crossover fashion with a 2-week washout period while maintaining habitual diet and physical activity patterns. The investigators hypothesize that consumption of a ketone drink will reduce BP and improve vascular health by reducing aortic pulse wave velocity and increasing brachial artery flow mediated dilation. Furthermore, they hypothesize that ketone consumption will improve cognitive health by increasing attention and processing speed.
Key facts
- Study ID
- NCT04236388
- Run by
- Virginia Polytechnic Institute and State University
- People needed
- 11
- Starts
- 2020-10-02
- Expected to finish
- 2022-05-25
- Last updated by the study team
- 2026-03-27
Who can join
Age: 50 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Ability to provide informed consent
- 50-75 years of age
- Systolic blood pressure <160 mmHg
- Diastolic blood pressure <100 mmHg
- Sedentary to recreationally active
- Body Mass Index <35 kg/m\^2
- Postmenopausal women must be >1 year since last menses
You may not qualify if…
- Current smoker
- Pregnant or planning to become pregnant
- Dyslipidemia (Total cholesterol >240 mg/dL, LDL >160 mg/dL)
- Chronic clinical disease (e.g., inflammatory bowel disease/irritable bowel syndrome, unstable coronary heart disease, stroke, heart failure, diabetes, neurological disorders)
- Following an extreme dietary pattern or planning to change to one (e.g., low carbohydrate, carnivore)
- Not weight stable in the prior 3 months (>2 kg weight change)
Where it is running
- Virginia Polytechnic and State University — Blacksburg, Virginia, United States
Full record on ClinicalTrials.gov
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