Physical Resilience: Indicators and Mechanisms in the Elderly (PRIME) Collaborative Phase 2

Completed

Conditions studied: Resilience, Aging

In brief

The purpose of this study is to examine underlying physical resilience (the ability to bounce back) in response to a specific stressor (total knee replacement).

Key facts

Study ID

NCT04235309

Run by

Duke University

People needed

297

Starts

2020-02-27

Expected to finish

2023-10-30

Last updated by the study team

2025-12-08

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 60 years of age or older
• Ability to speak English
• Planned elective knee replacement orthopedic surgery lasting 2 or more hours and requiring overnight observation or inpatient stay
• Community dwelling

You may not qualify if…

• Unable to ambulate independently, with or without assistive device
• Known dementia or screening 3MS score <=77
• Inmate of a correctional facility (i.e. prisoners)
• Active non-skin cancer or medical treatment for non-skin cancer with 12 months (chemotherapy, radiation, immunotherapy, hormonal therapy)
• Vision or hearing impairment that, after best accommodation, prevents reliable cognitive assessment (visual/hearing) and/or precludes telephone interviews (hearing)

Where it is running

• Duke Regional Hospital — Durham, North Carolina, United States
• Duke University Hospital — Durham, North Carolina, United States
• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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