Physiological Effects of ANGPTL3 Variants in Humans
Recruiting now · Not applicable
Conditions studied: Hypocholesterolemia
In brief
To evaluate the role of ANGPTL3, on lipid metabolism. To explore the role of this protein on glucose metabolism.
Key facts
- Study ID
- NCT04234724
- Run by
- University of Pennsylvania
- People needed
- 50
- Starts
- 2020-12-01
- Expected to finish
- 2026-06-30
- Last updated by the study team
- 2025-09-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Subjects aged 18 or older meeting at least one of the following criteria
- Carrying genetic variants in the gene encoding for ANGPTL3,
- Unaffected controls matched for age, race, gender,
- Willing to follow study procedures
- Able to provide inform consent
You may not qualify if…
- Any medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
- Taking any medication that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
- Women that are pregnant or nursing
- History of liver disease or abnormal liver function tests (>2x upper limit of normal)
- History of kidney disease or chronic renal insufficiency (eGFR <60 mL/min/1.73 m2)
- Uncontrolled hypertension (>160/100 mmHg)
- Uncontrolled diabetes
- Anemia (hemoglobin <11.0 mg/dL) History of a non-skin malignancy within the previous 5 years Major surgery within the past 3 months
- History of any organ transplant
- History of alcohol or drug abuse
- Participation in clinical trials assessing the efficacy and safety of drugs affecting lipid metabolism within the past 6 weeks (or longer depending on the known half-life of the drug) that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
- Inability to comply to study procedures
Where it is running
- University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.