Zn-DDC to Target Hypoxia-NFkappaB-CSCs Pathway in Multiple Myeloma
Recruiting now
Conditions studied: Multiple Myeloma
In brief
The outlook for patients with haematological malignancies remains challenging. It has been shown in some early cancer studies that a particular drug called Zn-DDC otherwise known as Imuthiol is highly toxic to cancer stem cells. Imuthiol has been intravenously used in clinical trials with an excellent safety record. Recent novel therapy and immunotherapy in haematological malignancies have improved outcome and survival but come with an increasing cost burden. Imuthiol could be an ideal affordable drug to study on it's own as well as in combination with other drugs in myeloma and other haematological malignancies. This may lead to potential combination therapies which will be very effective as well as affordable in the future. There is the need to look to see if this drug, Imuthiol and along with complementary drugs lenalidomide (Revlimid) and pomalidomide (Pomalyst) can help in haematological malignancy treatment. In order to do this there is the need to see how the cancer cells respond to the drugs in the laboratory before being able to trial the drug (or combination of drugs) out for treatment. The success of this study may lead to quick translation of Imuthiol into haematological malignancy treatment.
Key facts
- Study ID
- NCT04234022
- Run by
- The Royal Wolverhampton Hospitals NHS Trust
- People needed
- 70
- Starts
- 2021-10-22
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-04-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients diagnosed with haematological malignancy - either myeloma or acute leukaemia
- Patients must be 18 years or over
- Patients must be willing and able to give informed consent
You may not qualify if…
- Pregnant patients will not be entered
Where it is running
- The Royal Wolverhampton NHS Trust — Wolverhampton, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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